Rebel Wilson’s GLP-1 news has been everywhere this week. Bravely, she opened up about her weight loss journey, her microdosing of GLP-1 drugs, and her new title as Noom’s Chief Wellness Ambassador. 

As Hollywood continues to embrace Ozempic and similar medications, Wilson is offering a candid look at what these drugs mean for her own health and career.

Rebel Wilson Reveals the Secret Behind Her Ozempic ‘Microdosing’ Routine

Rebel Wilson’s weight loss journey started back in 2020, when she declared it her “Year of Health.” 

Motivated by her plans for IVF and a desire to freeze her eggs, she committed to exercising daily, eating more protein, and improving her overall wellness. That year, she lost around 80 pounds and says she felt better than she had in decades.

But, the journey wasn’t without its challenges. Wilson has spoken about being diagnosed with polycystic ovarian syndrome (PCOS) in her early twenties, a condition that made losing weight difficult. 

Doctors initially prescribed birth control pills, which she now believes kept her hormones out of balance for years. Looking back, she wishes she had known earlier about options like GLP-1 medication.

The Role of Rebel Wilson’s GLP-1 Microdosing

GLP-1 microdosing is a newer approach to using medications such as Ozempic, Wegovy, and Mounjaro. Instead of taking full doses long-term, some people cycle on and off smaller amounts to maintain their weight or ease side effects. 

Rebel Wilson's Ozempic use fits into this category. She’s said that her doctor suggested GLP-1s as a more realistic option for maintaining progress after her initial transformation.

Wilson tried the approach leading up to her wedding in 2024, using a higher dose for a short period to feel confident in her dress. 

Since then, she’s continued microdosing while balancing the demands of motherhood, acting, and long workdays. She admits it’s not about chasing a number on the scale anymore, but about finding stability during stressful times.

Noom Chief Wellness Ambassador

This month, Wilson added another title to her résumé: Noom Chief Wellness Ambassador. The role puts her at the center of the company’s new campaign, which focuses on “microhabits” like daily step goals, healthier snacks, and small changes that add up over time.

Alongside these behavioral tools, Noom now offers a GLP-1 program that includes education, coaching, and support for people prescribed the medications. 

Wilson says she likes that the platform combines science with approachable everyday habits, since weight loss drugs work best when paired with sustainable routines.

Hollywood and the Rise of Weight Loss Drugs

Rebel Wilson isn’t the only star speaking out. Hollywood weight loss drugs have become a cultural talking point, with celebrities like Oprah Winfrey and other big names confirming they’ve used GLP-1s. 

The rise of these drugs has fueled debates about representation, body image, and the pressures of fame.

Wilson has addressed the criticism head-on. She points out that, while some fans may feel celebrities are “abandoning” them by turning to weight loss drugs, the reality is more complicated. 

For her, these medications are about health, longevity, and being present for her daughter, not about fitting into an industry stereotype.

Where Rebel Wilson’s Health Journey Goes From Here

Rebel Wilson and GLP-1 conversations are helping reshape how we think about wellness. By sharing her experiences, she’s showing that health isn’t about perfection or extremes, but about finding the tools and habits that keep you feeling strong.

Her partnership with Noom reflects that same philosophy. Whether it’s GLP-1 microdosing, adding more movement into the day, or simply making kinder choices for herself, Wilson seems focused on the long game. 

And, as Hollywood continues to normalize these conversations, we may all start to feel more empowered to approach our own journeys with honesty and balance.